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13. Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents -- Park et al. 143 (2): 457 -- The Journal of Cell Biology
- www.jcb.org
- Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents .
- Previous reports have indicated that DNA-damaging treatments including certain anticancer therapeutics cause death of postmitotic nerve cells both in vitro and in vivo. ... Consequently, we examined whether cyclin-dependent kinase inhibitors (CKIs) and dominant-negative (DN) cyclin-dependent kinases (CDK) protect sympathetic and cortical neurons against DNA-damaging conditions. ... We also demonstrate that the CKIs p16 and p27 as well as DN-Cdk4 and 6 but not DN-Cdk2 or 3 protect cortical neurons from the DNA damaging agent camptothecin. ... These results suggest that postmitotic neurons may utilize Cdk4 and 6, signals that normally control proliferation, to mediate death signaling resulting from DNA-damaging conditions. ...
- JNK-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents.
14. News
- news.independent.co.uk
- Amnesty: 'Bankrupt' war on terror is world's most damaging conflict in 50 years.
- Amnesty: 'Bankrupt' war on terror is world's most damaging conflict in 50 years By Kim Sengupta 27 May 2004.
15. RediVolt, Inc - Surge Supression Solutions, TVSS
- www.redivoltmfg.com
- Protect your entire electrical system and equipment from damaging externally and internally generated harmful electrical transients. ...
16. Wood-Destroying Pests
- www.ces.ncsu.edu
17. BBC NEWS | Scotland | Airman fined for damaging helmets
- news.bbc.co.uk
- Airman fined for damaging helmets .
- Corporal Matthew James Elwood, of RAF Leuchars, was convicted of damaging RAF property at a court martial. ...
18. Personalizing the Earthquake Threat
- www.seis.utah.edu
- Many damaging earthquakes have occurred here since settlement, but most of today's inhabitants are unaware of them-and unaware of the impact they have had on people living in these communities. ...
19. Mechanisms of tolerance to DNA damaging therapeutic drugs -- Karran 22 (12): 1931 -- Carcinogenesis
- carcin.oupjournals.org
- Mechanisms of tolerance to DNA damaging therapeutic drugs .
- Tolerance to some DNA damaging drugs is accompanied by inactivation of the cell's DNA mismatch repair pathway. ...
- Despite the appeal and simplicity of the structure-based arguments, it is generally considered that MMR can process numerous DNA lesions and mediate the cytotoxicity of many DNA damaging treatments (Table I is adapted from two recent reviews, refs 16 and 17). ...
- In other words, there is nothing to suggest that the primary damage induced by bulky DNA damaging compounds is processed by MMR. ...
- Recombination is an acknowledged route for DSB repair and bacteria, yeast and mammalian cells with genetic defects in recombination are extremely sensitive to bulky DNA damaging agents of this type. ...
- Occasionally, MMR-defective cells do not appear to be particularly resistant to bulky DNA damaging drugs (37). ...
- This is known to affect the sensitivity of cells to numerous DNA damaging drugs, and in particular to cisplatin (48,49). ...
- With the obvious exceptions of methylating agents and 6-TG, MMR status is unlikely to have predictive value for responsiveness of tumours to therapeutic DNA damaging drugs. ...
- Pragmatically, the inability to process DSBs by MMR may be associated with resistance to multiple DNA damaging agents. ...
- Dependence of the Cytotoxicity of DNA-Damaging Agents on the Mismatch Repair Status of Human Cells.
20. Earthjustice: Newsroom
- www.earthjustice.org
- Bush Administration Approves Most Damaging Change to Clean Water Act in Decades .
21. Study Identifies Damaging Mechanism In Transplants And Heart Attacks
- www.sciencedaily.com
- Study Identifies Damaging Mechanism In Transplants And Heart Attacks.
- Ischemia/reperfusion injury is a common, damaging component of organ transplantation, heart attack, and stroke and is a determinant of organ failure in all cases. ...
22. WorldNetDaily: University considering Ward Churchill buyout
- www.worldnetdaily.com
- Daily publicity over controversial professor, faculty protests damaging school's reputation.
23. News - Long Term Economic Impact Of HIV/AIDS More Damaging Than Previously Thought
- web.worldbank.org
- Long Term Economic Impact Of HIV/AIDS More Damaging Than Previously Thought.
- In this way, the damaging impact of HIV/AIDS on economic growth over the longer run is intensified. ...
24. NPR : Report Says U.S. Deficits Could Cause Damaging Correction
- www.npr.org
- Deficits Could Cause Damaging Correction.
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