Making Documentary Films and Reality Videos : A Practical Guide to Planning, Filming, and Editing Documentaries of Real Events SELF-EDITING FOR FICTION WRITERS: How to Edit Yourself into Print Editing by Design: For Designers, Art Directors, and Editors-The Classic Guide to Winning Readers Self-Editing for Fiction Writers Final Cut Express for Dummies Premiere Pro Editing Workshop Vegas 5 Editing Workshop (DV Expert) The Eye is Quicker : Film Editing: Making A Good Film Better The Conversations : Walter Murch and the Art of Editing Film

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• The challenge of target sequence specificity in CU RNA editing .
• These co- and posttranscriptional regulatory events include capping, alternative splicing, differential polyadenylation, RNA editing, nuclear export, alternative decay and degradation pathways, as well as alterations in ribosomal loading or translation. Recent advances suggest important links between RNA editing, particularly CU editing, and other co- and posttranscriptional events regulating gene expression. ...
• Forms of RNA editing in mammalian cells.
• In RNA editing, the coding sequence of the transcript is altered from its genomically templated version. In mammals, two major types of RNA base-modification have been described, both forms of substitutional editing, in which a single nucleotide is altered posttranscriptionally (reviewed in ref. ... These include adenosine-to-inosine (AI) and cytidine-to-uridine (CU) editing. ...
• Mammalian AI RNA editing occurs on an unspliced mRNA template and requires partial base pairing between exonic and adjacent intronic sequences in a double-stranded RNA conformation. Inosine is translated as guanosine in the edited mRNA, so the effect of editing mimics that of an AG change. Examples of transcripts that undergo AI editing include the calcium-gated glutamate receptor, GluR-B, as well as subtypes of the 5HT2c receptor and hepatitis virus (1). A family of adenosine deaminases acting on RNA (ADARs) is responsible for these AI editing events, all of which operate through hydrolytic deamination of a defined target transcript (2). ... These features of AI RNA editing, namely the cis-acting requirements, the range of targets, and the enzymatic machinery, serve as useful reference points in understanding the mechanisms regulating the second form of base-modification editing, CU RNA editing. ...
• CU RNA editing involves a site-specific deamination of cytidine in a nuclear transcript that is mediated by an enzyme complex. Physiological targets for mammalian CU editing are currently confined to nuclear mRNAs encoding apoB and neurofibromatosis type I (NF1) transcripts. CU RNA editing is mediated by an enzyme complex for which some but not all the component factors are known and which, unlike AI editing, requires a minimum of two protein components acting on a suitable template to reproduce targeted enzymatic deamination in vitro. ...
• The original and most fully detailed example of CU RNA editing is mammalian apoB mRNA, in which a site-specific cytidine deamination introduces a UAA stop codon into the translational reading frame, resulting in synthesis of a truncated protein, apoB48 (reviewed in ref. ... CU RNA editing of apoB occurs within enterocytes of the mammalian small intestine, as well as in the liver in some species (reviewed in ref. ... Under physiological circumstances, CU editing of apoB mRNA targets a single cytidine out of more than 14,000 nucleotides, a process constrained by stringency in the cis-acting elements and by the protein factors responsible for targeted deamination. ... This sequence is flanked by elements both 5' and 3' of a minimal, approximately 50-nucleotide editing cassette. ... The most plausible interpretation of these collective requirements is to coordinate optimal alignment of the substrate with respect to the active site of the editing enzyme. ...

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