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37. A 3'-flanking NF-kappa B site mediates developmental silencing of the human zeta -globin gene -- Wang and Liebhaber 18 (8): 2218 -- The EMBO Journal
- embojournal.npgjournals.com
- 2218-2228, 1999 A 3'-flanking NF-B site mediates developmental silencing of the human -globin gene .
- 1 kb of its 3'-flanking region. ...
- Nomenclature denotes the extent of 3'-flanking region. ...
- The developmental control of the h-globin expression is gene-autonomous; all the necessary information for appropriate developmental silencing is present within and/or directly flanking the -globin transgene and this control does not require cis interactions with the fetal/adult -globin gene (Albitar et al. ...
- The transcriptional activities of many structural genes are controlled by DNA sequences within the promoter and/or in the contiguous 5'-flanking region. ... Subsequent 5'-deletional mapping of this region revealed that a h-globin transgene with as little as 128 bp of 5'-flanking sequence is also normally regulated (Sabath et al. ... These studies suggest that cis-acting determinants required for stage-specific expression of the h-globin gene may reside within the transcribed or 3'-flanking sequences. ...
- Using transgenic models, silencing determinants have been identified in both the transcribed region and the 3'-flanking region of the h-globin gene (Liebhaber et al. ... , 1997, 1998) A second determinant of -globin gene silencing has been localized to its 3'-flanking region. ... 1 kb of contiguous 3'-flanking sequences exhibits proper developmental regulation with a 50-fold decrease in -globin mRNA levels from day 9. ... In contrast, truncation of the 3'-flanking region to 106 bp 3' to the poly(A) addition site significantly blunted silencing to a 10-fold decrease over the same developmental window (Liebhaber et al. ... The transcriptional silencing mediated by the 3' flanking region can be detected as early as day 8. ... Thus, the combined effects of transcriptional silencing by the 3'-flanking region and accelerated clearance of residually expressed -globin mRNA can account for most if not all of the developmental control observed for the intact -globin transgene (Liebhaber et al. ... While the cis and trans determinants of -globin mRNA instability have been studied in detail (Russell and Liebhaber 1998), the basis for silencing activity of the 3'-flanking region remains undefined. In the present report, we map, characterize and functionally test a cis determinant positioned within the 3'-flanking region of the h-globin gene, which mediates developmental silencing. ...
- 55 kb of 5'-flanking sequences and 2. 1 kb of 3'-flanking sequences is silenced 50-fold during the transition from primitive erythropoiesis (day 9. ... This developmental control is markedly blunted by truncation of the 3' flanking region suggesting that an element(s) critical to full silencing is located in this region (see Introduction). ... 1 kb of contiguous 3'-flanking sequence, with the HS-40 transgene that is truncated 106 bp 3' to the poly(A) addition site (Figure 1B). ... These data substantiated the previous assignment of a silencing determinant to the 3'-flanking region and confirmed equivalent developmental control of the h-globin transgene in the presence of the major regulatory elements derived from either the - or the -globin gene clusters. ...
38. Special Paper 318: Pliocene carbonates and related facies flanking the Gulf of California, Baja California, Mexico
- www.gsajournals.org
- Special Paper 318: Pliocene carbonates and related facies flanking the Gulf of California, Baja California, Mexico.
39. EBM -- Sign In Page
- www.ebmonline.org
- Characterization of the 5'-Flanking Transcriptional Regulatory Region of Chicken.
40. The LSP-2 gene and a 5' flanking sequence are independently expressed in Drosophila melanogaster
- www.nature.com
- The LSP-2 gene and a 5' flanking sequence are independently expressed in Drosophila melanogaster .
- 5 kilobases (kb) of DNA flanking the 5' end of the LSP-2 coding region. ...
41. Kamat's Potpourri: Genitalia Worship: Linga Worship
- www.kamat.com
- Devotees Flanking a Lingam.
42. 5' Flanking Variants of Resistin Are Associated With Obesity -- Engert et al. 51 (5): 1629 -- Diabetes
- diabetes.diabetesjournals.org
- 5' Flanking Variants of Resistin Are Associated With Obesity .
- An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g. ...
43. Development of Flanking Line: grows in the southwestern portion of the cluster
- ww2010.atmos.uiuc.edu
- Development of Flanking Line grows in the southwestern portion of the cluster .
- Image: flanking line (59K) .
- The new development, called the flanking line, is at the left (southwest) side of the complex. ...
44. Entrez PubMed
- www.ncbi.nlm.nih.gov
- Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
- The mechanism by which nucleotides flanking the ATG codon might exert their effect is discussed.
45. Marketing Terms Dictionary - American Marketing Association - www.marketingpower.com
- www.marketingpower.com
- flanking.
- Flanking can be executed by targeting either a geographical segment or a consumer segment (group) that is not being well served by competitors, when the competitor is unwilling or unable to retaliate. ...
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