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13. The voltage-gated Kv1.3 K+ channel in effector memory T cells as new target for MS -- Wulff et al. 111 (11): 1703 -- Journal of Clinical Investigation
- www.jci.org
- The voltage-gated Kv1. ...
- Following activation, TEM cells expressed significantly higher levels of the voltage-gated K+ channel Kv1. ...
- Modulation of Voltage-Gated Potassium Channels in Human T Lymphocytes by Extracellular Glutamate.
- Voltage-Gated Potassium Channels in Cell Proliferation.
14. North Carolina Outer Banks at Pirates Cove - Fishing, vacation rentals, real estate & more
- www.pirates-cove.com
- Cove is a 24 hour security gated resort and .
15. Cloned Human Aquaporin-1 Is a Cyclic GMP-Gated Ion Channel -- Anthony et al. 57 (3): 576 -- Molecular Pharmacology
- www.molpharm.org
- Cloned Human Aquaporin-1 Is a Cyclic GMP-Gated Ion Channel .
- We show here that cloned human AQP1 not only mediates water flux but also serves as a cGMP-gated ion channel. ... Amino acid sequence alignments between AQP1 and sensory cyclic-nucleotide-gated channels showed similarities between the cyclic-nucleotide-gated binding domain and the AQP1 carboxyl terminus that were not present in AQP5. ...
- This subunit structural motif also is a hallmark of the ion channel gene family that includes potassium channels and cyclic-nucleotide-gated (CNG) channels from retinal and olfactory cells (Jan and Jan, 1992). ...
- From BioLog, Life Science Institute (La Jolla, CA), we obtained -phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphoro-thioate Rp-isomer (Rp-8-Br-PET-cGMPS), an inhibitor of cGMP-dependent protein kinase and of retinal cGMP-gated ion channels; -phenyl-1,N2-ethano-8-bromoguanosine-3',5'-cyclic monophosphoro-thioate Sp-isomer (Sp-8-Br-PET-cGMPS), an inhibitor of retinal cGMP-gated channels but an activator of cGMP-dependent protein kinase; and 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate (8-pCPT-cGMP), an activator of cGMP-gated ion channels and of cGMP-dependent protein kinase. ...
- Alignment of the carboxyl-terminal domains of AQP1, AQP5, and cyclic nucleotide-gated channels. ...
- Specifically, Sp-8-Br-PET-cGMPS is an inhibitor of retinal cGMP-gated channels but an activator of cGMP-dependent protein kinase. ... The effects of the other agents also support the similarities in pharmacology between AQP1 and the CNG channels, in that 8pCPT-cGMP is an activator of both cGMP-gated ion channels and of the ionic current in AQP1-expressing oocytes, whereas Rp-8-Br-PET-cGMPS is an inhibitor of both retinal cGMP-gated ion channels and of the ionic conductance in AQP1-expressing oocytes. ...
- The broader family of ion channels (K+ channels, CNG channels, and other voltage-gated channels) contains pore-lining sequences in the S5-S6 loops, with the pore formed in the center of the tetramer of subunits (Jan and Jan, 1992). ...
- Previously unrecognized clues to the function of AQP1 as a cGMP-gated ion channel may exist in the published literature (e. ...
- AQP1, aquaporin-1; Sf9, Spodoptera frugiperda; AQP5, aquaporin-5; CNG, cyclic nucleotide gated; MIP, membrane intrinsic protein; 8-Br-cAMP, 8-bromo-cAMP; PKA, protein kinase A; H7, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride; RP-8-Br-PET-cGMPS, -phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphoro-thioate Rp-isomer; 8-pCPT-cGMP, 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate; SP-8-Br-PET-cGMPS, -phenyl-1,N2-ethano-8-bromoguanosine-3',5'-cyclic monophosphoro-thioate Sp-isomer; SSC, standard saline citrate. ...
- Bradley J, Li J, Davidson N, Lester HA and Zinn K (1994) Heteromeric olfactory cyclic nucleotide-gated channels: A new subunit that confers increased sensitivity to cAMP. ...
- Goulding EH, Ngai J, Kramer RH, Colicos S, Axel R, Siegelbaum SA and Chess A (1992) Molecular cloning and single channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. ...
- Goulding EH, Tibbs GR and Siegelbaum SA (1994) Molecular mechanism of cyclic-nucleotide-gated channel activation. ...
- Kaupp UB, Niidome T, Tanabe T, Terada S, Boenigk W, Stuehmer W, Cook NJ, Kangawa K, Matsuo H, Hirose T, Miyata T and Numa S (1989) Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP- gated channel. ...
- Molokanova E, Trivedi B, Savchenko A and Kramer RH (1997) Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation. ...
16. Voltage-Gated Potassium Channels in Cell Proliferation -- Pardo 19 (5): 285 -- Physiology
- physiologyonline.physiology.org
- REVIEW Voltage-Gated Potassium Channels in Cell Proliferation .
17. Ca2+ permeation in cyclic nucleotide-gated channels -- Dzeja et al. 18 (1): 131 -- The EMBO Journal
- embojournal.npgjournals.com
- 131-144, 1999 Ca2+ permeation in cyclic nucleotide-gated channels .
- Cyclic nucleotide-gated (CNG) channels conduct Na+, K+ and Ca2+ currents under the control of cGMP and cAMP. ...
- Cyclic nucleotide-gated (CNG) channels of vertebrates are cation channels controlled by the cytosolic concentration of cGMP or cAMP (for recent reviews, see Kaupp, 1995; Biel et al. ...
- In a pioneering work on photoreceptors, Nakatani and Yau (1988) measured the contribution of Ca2+ to the dark current conducted by cGMP-gated channels in the plasma membrane of the rod outer segment. ...
- Although there is no additional independent evidence for double occupancy by Ca2+ ions yet, it represents an attractive concept for the explanation of the shape of Pf/ Ca2+ o relationships, which is based on the similarities between CNG channels and voltage-gated Ca2+ channels for which this scheme of Ca2+ permeation was developed (Tsien et al. ...
- Comparison of CNG channels and voltage-gated Ca2+ channels .
- Comparison of similarities and differences between CNG channels and voltage-gated Ca2+ channels can help to understand the permeation mechanism in CNG channels. In homomeric CNG channels and in voltage-gated Ca2+ channels, a set of four glutamate residues forms the cation-binding site in the pore (Kim et al. ... Micromolar concentrations of extracellular Ca2+ block monovalent currents in both channel types, but voltage-gated Ca2+ channels show higher Ca2+ affinity (Ki of ~1 µM) compared with CNG channels (Ki values in the range of 6-300 µM). ... , 1995; this study), and by observation of anomalous mole-fraction behavior with voltage-gated Ca2+ channels (Tsien et al. ... Finally, current recordings at high concentrations of the charge carriers have revealed a similar efficiency of Ca2+ permeation: the single-channel conductance of voltage-gated Ca2+ channels from ventricular heart cells is 85 pS with 150 mM Na+ and 9 pS with 110 mM Ca2+ (Hess et al. ... First, the higher Ca2+ affinity of voltage-gated Ca2+ channels causes a virtually complete suppression of monovalent currents and produces pure Ca2+ currents at 1-2 mM Ca2+ o, whereas the known native CNG channels conduct mixed cation currents at this Ca2+ o (Nakatani and Yau, 1988; Perry and McNaughton, 1991). Secondly, both channel types can co-assemble with various modulatory subunits, but while the high-affinity binding site is preserved in voltage-gated Ca2+ channels (De Waard et al. ... Thirdly, despite their high Ca2+ affinity, voltage-gated Ca2+ channels conduct substantial Ca2+ currents, possibly sustained by electrostatic repulsion of two Ca2+ ions that can occupy the pore at the same time. ... In conclusion, several structural features common to both channel types give rise to pure Ca2+ currents in voltage-gated Ca2+ channels and to mixed cation currents with a high Ca2+ fraction in CNG channels. ...
- As cyclic nucleotide-gated (CNG) Ca2+ channels, their contribution to Ca2+ signaling would be much more pronounced than their effect on membrane voltage. Although their Ca2+ conductance is low compared with voltage-gated Ca2+ channels, the channels can mediate considerable Ca2+ influx because they show no intrinsic inactivation and can, therefore, conduct persistent Ca2+ currents at hyperpolarized voltages. ... Ca2+ influx is rapid, because Ca2+ ions bind less tightly to the pore, and transfer rates approach those reported for voltage-gated Ca2+ channels. ...
18. The effects of general anaesthetics on ligand-gated ion channels -- Dilger 89 (1): 41 -- British Journal of Anaesthesia
- bja.oupjournals.org
- The effects of general anaesthetics on ligand-gated ion channels .
19. Cyclic Nucleotide-Gated Ion Channels -- Kaupp and Seifert 82 (3): 769 -- Physiological Reviews
- physrev.physiology.org
- Cyclic Nucleotide-Gated Ion Channels .
- MOLECULAR DIVERSITY OF CYCLIC NUCLEOTIDE-GATED CHANNEL SUBUNITS.
- Comparison of CNG Channels and Voltage-Gated Ca2+ Channels.
- Cyclic Nucleotide-Gated Ion Channels. ... Cyclic nucleotide-gated (CNG) channels are nonselective cation channels first identified in retinal photoreceptors and olfactory sensory neurons (OSNs). ... Although their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated K+ channels, CNG channels form heterotetrameric complexes consisting of two or three different types of subunits. ...
- Ion channels that are directly activated by cyclic nucleotides cyclic nucleotide-gated (CNG) channels are relatively recent arrivals in the world of ion channels. ...
- Other members of this superfamily are the so-called hyperpolarization-activated and cyclic nucleotide-gated (HCN) pacemaker channels (for review, Ref. ...
- Unlike ligand-gated neurotransmitter receptors, CNG channels do not desensitize in the continuous presence of the ligand. ...
- Ca2+ feedback mechanism in rod and cone photoreceptors involving cyclic nucleotide-gated channels. ...
- Quite remarkably, a cousin of the retinal CNG channels takes center stage in odorant signaling; the vast majority of OSNs respond to brief pulses of odorants with a transient receptor current by opening cAMP-gated channels in the ciliary membrane (107, 293). ...
- Transcripts encoding a CNG channel subunit have been amplified from cultured human Müller cells using primers specific for the A1 subunit of the cGMP-gated channel of rod photoreceptors. ...
- MOLECULAR DIVERSITY OF CYCLIC NUCLEOTIDE-GATED CHANNEL SUBUNITS .
- Roman letters have been previously used to classify the subunits of several families of ligand-gated channels. ...
- Genomic structure of cyclic nucleotide-gated (CNG) channel genes. ...
20. City of Rolling Hills Home Page
- www.palosverdes.com
- Rolling Hills is a private, gated community located atop the scenic hills of the Palos Verdes Peninsula, CA. ...
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