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13. DNA Microarrays (Genome Chips) (by Leming Shi, PhD)
- www.gene-chips.com
- Leming Shi Systems biology and toxicology, Data mining for DNA microarray gene expression profiling, SELDI-TOF protein profiling, and NMR metabolic profiling, Knowledge discovery, data mining, and visualization in chemistry and biology, Bioinformatics, chemoinformatics, toxicoinformatics, and chemometrics, Identification of disease-related genes, Computer-aided drug design and toxicity prediction, Structure-based drug design, Molecular diversity analysis and combinatorial library design, Pharmacophore identification and 3D database searching, Databases, expert systems, machine learning, and artificial intelligence, Chemical and biological information exchange on the WWW Toxicoinformatics, systems toxicology, systems biology Lshi 8 37 2005-01-23T23:24:00Z 2005-01-23T23:38:00Z 1 27259 155380 microarrays, bioinformatics, database, quality control, gene expression, Affymetrix, FDA/NCTR 1294 364 182275 10. ...
- Gene-Chips. ...
- However, traditional methods in molecular biology generally work on a "one gene in one experiment" basis, which means that the throughput is very limited and the "whole picture" of gene function is hard to obtain. ...
- Terminologies that have been used in the literature to describe this technology include, but not limited to: biochip, DNA chip, DNA microarray, and gene array. ... However, in some articles appeared in professional journals, popular magazines, and the WWW the term "gene chip(s)" has been used as a general terminology that refers to the microarray technology. Affymetrix strongly opposes such usage of the term "gene chip(s)". ...
- DNA microarray, or DNA chips are fabricated by high-speed robotics, generally on glass but sometimes on nylon substrates, for which probes* with known identity are used to determine complementary binding, thus allowing massively parallel gene expression and gene discovery studies. ...
- There are two major application forms for the DNA microarray technology: 1) Identification of sequence (gene / gene mutation); and 2) Determination of expression level (abundance) of genes. ...
- For a very well-written introduction on the steps involved in a microarray experiment, visit Jeremy Buhler's Anatomy of a Comparative Gene Expression Study .
- Gene discovery .
- Although they are not the "traditional" gene chip or microarray, I decided to list related links at this site because of their close connection and integration to the gene chip (microarray) technology.
- First Preclinical Toxicity Application (Toxicology EXPRESS™ database using Gene Logic's Flow-thru Chip™ technology) between Wyeth-Ayerst Research and Gene Logic .
- Reinke V, Smith HE, Nance J, Wang J, Van Doren C, Begley R, Jones SJ, Davis EB, Scherer S, Ward S, Kim SK Stanford A global profile of germline gene expression in C. ...
- Genomics, gene expression and DNA arrays. ...
- A gene expression database for the molecular pharmacology of cancer. ...
- Systematic variation in gene expression patterns in human cancer cell lines. ...
14. Mammalian Gene Collection
- mgc.nci.nih.gov
- MAMMALIAN GENE COLLECTION.
- About the MGC The goal of the Mammalian Gene Collection (MGC), a trans-NIH initiative, is to provide full-length open reading frame (FL-ORF) clones for human, mouse, and rat genes. ... However, recently, alternative methods based on gene specific primers have been developed to target the recovery of genes absent from the MGC collection. ...
- Search for Full-length MGC Clones by Gene Symbol or Keyword Select Human or Mouse or Rat .
- Enter Gene Symbol .
- Enter Gene Keyword .
- For information about the Mammalian Gene Collection contact MGC Information. ...
15. Avigen Inc. Home Page
- www.avigen.com
- Avigen is a leader in the development of gene therapy products to treat serious, chronic diseases. Our gene therapy products are designed for in vivo administration to achieve the production of therapeutic proteins within the body. We are developing a new broad-based proprietary gene delivery technology - AAV (adeno-associated virus vectors) for use in the clinic. ...
- Avigen Cleared by FDA to Begin Gene Therapy Trial for Parkinson's Disease.
- What is Gene Therapy? .
- The advent of gene therapy has provided new hope for these patients. Gene therapy involves delivering, not a therapeutic protein itself, but a gene for the protein. Avigen's first two product candidates utilize a small harmless human virus called adeno-associated virus (AAV) to deliver the therapeutic gene. AAV's own genes are removed, and the therapeutic gene inserted. AAV can then deliver the gene to the patient's cells, turning the patient's own cells into small "factories" that can make the protein. ...
- What is Gene Therapy?.
16. The Human Gene Mutation Database (HGMD)
- www.uwcm.ac.uk
- Welcome to the Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff.
- If you refer to HGMD in any publication, please cite Stenson et al (2003), The Human Gene Mutation Database (HGMD®): 2003 Update. ...
17. Harvard Gene Therapy Initiative
- hgti.med.harvard.edu
- Gene Therapy Initiative .
- The Harvard Gene Therapy Initiative was founded with the objective of promoting the use of gene therapy in both research and therapeutic applications and to conduct research developing new gene delivery vector technologies. ...
18. spliceNest - prediction of gene structure and alternative splicing based on EST consensus sequences
- splicenest.molgen.mpg.de
- SpliceNest: visualization of gene structure and alternative splicing based on EST clusters. ...
19. OBO Main
- obo.sourceforge.net
- Gene Ontology Consortium .
- The goal of the Gene Ontology (GO) consortium is to produce a controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes. ...
- The Sequence Ontology (SO) is a part of the Gene Ontology project and the aim is to develop an ontology suitable for describing biological sequences. ...
- The Microarray Gene Expression Data (MGED) Society is an international organisation of biologists, computer scientists, and data analysts that aims to facilitate the sharing of microarray data generated by functional genomics and proteomics experiments. ...
20. URTH: Discussion of the works of Gene Wolfe
- www.urth.net
- This is the home page of the Urth List, an email discussion group about the works of Gene Wolfe. ...
21. GeNet home page
- www.csa.ru
22. FatiGO Data mining with Gene Ontology
- fatigo.bioinfo.cnio.es
- FatiGO Data mining with Gene Ontology .
- Data mining with Gene Ontology Help .
- FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. ...
23. NTC's Vector Solutions, including plasmid DNA production, recombinant proteins and vector development, Fermentation Technology and Media
- www.natx.com
- Nature Technology Corporation (NTC) is a technology-based molecular biology and gene therapy services company, providing expert vector development as well as plasmid DNA and recombinant protein manufacturing services for biotechnology and pharmaceutical companies worldwide. ... NTC technologies include gene self-assembly (GENSA), Promoter rescue technology (PROREST), VLVectors (retrotransposons, VL30 retro-vectors), traditional retroviral vectors, DNA vaccines and HyperGRO fermentation media for plasmid and recombinant protein production. ...
24. the Gene Ontology website
- www.geneontology.org
- gene or protein name .
- GENE ONTOLOGY.
- What is the Gene Ontology? .
- The goal of the Gene Ontology project is to produce a controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes. ...
- GO term gene or protein name .
- the tasks performed by individual gene products; examples are carbohydrate binding and ATPase activity .
- Answers to questions that are very commonly asked about the Gene Ontology. ...
- A description of the aims of the Gene Ontology Consortium and an explanation of how the ontologies work. ...
- Two XML files are available, one with gene associations and one without. ...
- - A general page for software developed by the Gene Ontology Database group at UC Berkeley provides downloads and source. ...
- A record of the Gene Ontology home page usage statistics. ...
- The Gene OntologyTM project thanks for financial support. ...
- The Gene Ontology Consortium is supported by an P41 grant from the National Human Genome Research Institute (NHGRI) grant HG002273 and by grants from the European Union RTD Programme "Quality of Life and Management of Living Resources" QLRI-CT-2001-00981 and QLRI-CT-2001-00015 . ...
- The Gene Ontology Consortium would like to acknowledge the assistance of many more people than can be listed here. ...
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